Pathways
Polyamine Metabolism in Intestinal Cells
Description:
The amino-acid derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumor suppressor genes regulate polyamine metabolism. Polyamines are organic cations that are derived from amino acids and occur in all organisms. Putrescine, Spermidine and Spermine are the main polyamines found in prokaryotes and eukaryotes. Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both electrostatically and covalently and, as a consequenc...
References:
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Polyamines and Cancer.
Methods Mol Biol. 2018;1694:469-488. doi: 10.1007/978-1-4939-7398-9_39. -
Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease.
Front Chem. 2018 Feb 5;6:10. doi: 10.3389/fchem.2018.00010. -
Polyamines and their metabolites as diagnostic markers of human diseases.
Biomol Ther (Seoul). 2013 Jan;21(1):1-9. doi: 10.4062/biomolther.2012.097. -
Modulation of learning and memory by natural polyamines.
Pharmacol Res. 2016 Oct;112:99-118. doi: 10.1016/j.phrs.2016.03.023. Epub 2016 Mar 22.
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