Pathways
Polyamine Regulation in Colon Cancer
Description:
Polyamines are vital for the growth and function of normal cells. The complexity of polyamine metabolism and the multitude of compensatory mechanisms that are invoked to maintain polyamine homoeostasis argue that these amines are critical to cell survival. The regulation of polyamine content within cells occurs at several levels, including transcription and translation (Ref.1). The amino-acid derived polyamines like Putrescine, Spermidine and Spermine that are the main polyamines found in prokaryotes and eukaryotes, have long...
References:
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The old and new biochemistry of polyamines.
Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):2053-2068. doi: 10.1016/j.bbagen.2018.06.004. Epub 2018 Jun 8. -
Polyamines in aging and disease.
Aging (Albany NY). 2011 Aug;3(8):716-32. doi: 10.18632/aging.100361. -
Polyamine metabolism and cancer: treatments, challenges and opportunities.
Nat Rev Cancer. 2018 Nov;18(11):681-695. doi: 10.1038/s41568-018-0050-3. -
Structural basis of antizyme-mediated regulation of polyamine homeostasis.
Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11229-34. doi: 10.1073/pnas.1508187112. Epub 2015 Aug 24.
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