Pathways
Poxvirus Infection Cycle
Description:
Poxviridae is a family of viruses containing large double-stranded DNA genomes of 130,000 to >300,000 nucleotides. Humans, vertebrates, and arthropods serve as natural hosts. Poxviridae viral particles (virions) are generally enveloped (external enveloped virion), though the intracellular mature virion form of the virus, which contains different envelope, is also infectious. They vary in their shape depending upon the species but are generally shaped like a brick or as an oval form similar to a rounded brick because ...
References:
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Challenges and Achievements in Prevention and Treatment of Smallpox.
Vaccines (Basel). 2018 Jan 29;6(1):8. doi: 10.3390/vaccines6010008. -
The structure of the poxvirus A33 protein reveals a dimer of unique C-type lectin-like domains.
J Virol. 2010 Mar;84(5):2502-10. doi: 10.1128/JVI.02247-09. Epub 2009 Dec 23. -
Smallpox as a biological weapon: implications for the critical care clinician.
Dimens Crit Care Nurs. 2003 Jan-Feb;22(1):2-7; quiz 8-9. doi: 10.1097/00003465-200301000-00001. -
Poxvirus DNA replication.
Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9):a010199. doi: 10.1101/cshperspect.a010199.
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