St. Louis, MO and San Diego, CA, December 14, 2005 - Sigma-Aldrich has licensed 100 signal transduction pathways from ProteinLounge.com. These pathways illustrate protein interaction and cellular signaling maps. Sigma will use these pathways for placement on their web site and print marketing. The pathways will allow researchers to more easily find Sigma products related to signal transduction components.

San Diego, CA and Maynard, MA, September 3, 2004 - Protein Lounge, a provider of biological pathways and other systems biology databases, and OmniViz, Inc., a leading provider of advanced visual informatics software, components, and services, announce their collaborative effort to make Protein Lounge content deployable within the OmniViz Pathway Enterprise™ (OPE) software. OmniViz will become the exclusive distributor for Protein Lounge’s pathway content within informatics software. OPE is a full-featured pathway display, drawing, and analysis package that supports enterprise-wide sharing and searching. The underlying biological object model allows semantic integration of data, which is required when dealing with multiple users and multiple sources of information, and inherently creates a complete cross-reference of all components. OPE provides support for textbook-style drawings, including entities such as cellular components and membranes, but with interactive objects that can be color-coded according to experimental data and linked to literature analysis. "OPE is designed to support data from all of the sources needed by our customers. The Protein Lounge pathways are rich in content and have an exceptional three-dimensional presentation that also conveys context," said Dr. Jeffrey Saffer, President of OmniViz. Being able to offer these pathways as part of a bundled solution adds to the growing value of the OPE platform." Protein Lounge has over 300 manually curated cell signaling and biosynthetic pathways. Each pathway includes a detailed description and references. The content is further supported by detailed information about each protein or molecule. "Having OmniViz as the distributor for our pathway content will expand availability of our pathways to the commercial arena," said Dr. Samik Singh, CEO of Protein Lounge. "OPE’s enterprise-level solution provides a versatile framework for our content and will allow companies to utilize those pathways within the larger context needed for discovery."

SAN DIEGO, CA, August 16, 2004 - Protein Lounge has developed a database which contains antigenic peptide targets against all know proteins throughout a variety of organisms. This is the first of such databases. This Peptide Antigen Database was developed using Protein Lounge's proprietary algorithm which distinguishes the most antigenic regions of a protein. All peptide targets are linked to Protein Lounge's online hyrdoplotting tool, which allows you to view an interactive version of the protein sequence on a hydrophilicity/phobicity plot. This is a necessary database for anyone working with antibody or drug development. This database will greatly increase the speed at which a drug discovery company will be able to distinguish protein drug targets. The most important aspect in the production of antibodies or drugs is the design of the peptide-antigen. A peptide-antigen is a small segment (15-18 amino acids) of the protein sequence of interest. These peptide-antigens can be used for immunization in order to produce antibodies against the protein or they can be used as a basis for small-molecule/drug targeting.

SAN DIEGO, CA, May 31, 2004 – Protein Lounge, a leader is systems biology databases and bioinformatics tools, today announced that EMD Biosciences has agreed to take a non-exculsive license of some of Protein Lounge’s signal transduction pathway images. Under the terms of the agreement EMD Biosciences will have a non-exculsive license for one-year to use 13 of Protein Lounge’s signal transduction pathway images. EMD will use these pathways in their web-based and printed marketing. EMD believes that the addition of these signal transduction pathways to their marketing will attract additional attention to their reagents made against the proteins of those pathways. Protein Lounge has licensed the following pathways to EMD:

• Alzheimer's Disease Pathway
• GSK3 Signaling
• Caspase Cascade
• Akt Signaling
• Mitochondrial Apoptosis Pathway
• p53 Signaling
• DNA Repair Mechanisms
• Cytokine network
• MAPK Family Pathway
• GPCR Pathway
• NFKB Family Pathway
• VEGF Pathway
• Insulin Pathway