Pathways
Prion Pathway
Description:
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders affecting humans and animals. Human TSEs are often categorized with other protein misfolding neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease, Huntington’s disease, fronto-temporal dementia and amyotrophic lateral sclerosis. The mechanism of disease propagation is well understood and involves the conformational conversion of a normal cell-surface protein (PrPc) into a...
References:
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Mechanisms of prion-induced neurodegeneration.
Expert Rev Mol Med. 2016 Apr 8;18:e5. doi: 10.1017/erm.2016.8. Review. -
Characterization of mutations in PRNP (prion) gene and their possible roles in neurodegenerative diseases.
Neuropsychiatr Dis Treat. 2018 Aug 14;14:2067-2085. doi: 10.2147/NDT.S165445. eCollection 2018. Review. -
The biological function of the cellular prion protein: an update.
BMC Biol. 2017 May 2;15(1):34. doi: 10.1186/s12915-017-0375-5. Review. -
Prion degradation pathways: Potential for therapeutic intervention.
Mol Cell Neurosci. 2015 May;66(Pt A):12-20. doi: 10.1016/j.mcn.2014.12.009. Epub 2015 Jan 10. Review.
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