Pathways
Progesterone-Induced Oocyte Maturation in X. laevis
Description:
Oocyte maturation is the final process of oogenesis where the fully grown ooocytes undergo meiosis to become fertilizable. Oocyte maturation begins with the breakdown of the oocyte nucleus, the germinal vesicle (GV), which occurs by the rapid condensation of the chromosomes to the metaphase state which then move towards the animal pole and divide into two haploid sets and enter the meiosis II. Oocyte maturation in vertebrates is a complex process that requires several morphological, biochemical and ultra structural signalin...
References:
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Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time.
Endocrinology. 2018 Sep 1;159(9):3209-3218. doi: 10.1210/en.2018-00485. -
Aven is dynamically regulated during Xenopus oocyte maturation and is required for oocyte survival.
Cell Death Dis. 2013 Nov 7;4(11):e908. doi: 10.1038/cddis.2013.435. -
The role of Xenopus membrane progesterone receptor beta in mediating the effect of progesterone on oocyte maturation.
Mol Endocrinol.2007 Mar;21(3):664-73. doi: 10.1210/me.2006-0256. Epub 2006 Dec 21. -
Release from Xenopus oocyte prophase I meiotic arrest is independent of a decrease in cAMP levels or PKA activity.
Development. 2016 Jun 1;143(11):1926-36. doi: 10.1242/dev.136168. Epub 2016 Apr 27.
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