Pathways
Prolactin Signaling
Description:
PRL (Prolactin), a multifunctional hormone secreted by the anterior pituitary gland and to a lesser extent by numerous extrapituitary tissues, affects more physiological processes than all other pituitary hormones combined. It was originally identified by its ability to stimulate the development of the mammary gland and lactation. However, this hormone has been established to be present in all vertebrates, and involved in more than 300 separate effects, which can be ascribed to six broad categories: (i) reproduction and la...
References:
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Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone.
J Invest Dermatol. 2009 May;129(5):1071-87. doi: 10.1038/jid.2008.348. Epub 2008 Dec 25. Review. -
60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis.
J Endocrinol. 2015 Aug;226(2):T101-22. doi: 10.1530/JOE-15-0213. Epub 2015 Jun 22. Review. -
A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production.
Oncol Rep. 2018 Mar;39(3):1253-1260. doi: 10.3892/or.2018.6222. Epub 2018 Jan 19. -
Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer.
Breast Cancer Res. 2011 Oct 12;13(5):220. doi: 10.1186/bcr2921. Review.
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