Prolactin Signaling

Description:

PRL (Prolactin), a multifunctional hormone secreted by the anterior pituitary gland and to a lesser extent by numerous extrapituitary tissues, affects more physiological processes than all other pituitary hormones combined. It was originally identified by its ability to stimulate the development of the mammary gland and lactation. However, this hormone has been established to be present in all vertebrates, and involved in mo[...]

References:

Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone.
Foitzik K, Langan EA, Paus R.
J Invest Dermatol. 2009 May;129(5):1071-87. doi: 10.1038/jid.2008.348. Epub 2008 Dec 25. Review.
60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis.
Grattan DR.
J Endocrinol. 2015 Aug;226(2):T101-22. doi: 10.1530/JOE-15-0213. Epub 2015 Jun 22. Review.
A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production.
Ramírez De Arellano A, Riera Leal A, Lopez-Pulido EI, González-Lucano LR, Macías Barragan J, Del Toro Arreola S, García-Chagollan M, Palafox-Sánchez CA, Muñoz-Valle JF, Pereira-Suárez AL.
Oncol Rep. 2018 Mar;39(3):1253-1260. doi: 10.3892/or.2018.6222. Epub 2018 Jan 19.
Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer.
Furth PA, Nakles RE, Millman S, Diaz-Cruz ES, Cabrera MC.
Breast Cancer Res. 2011 Oct 12;13(5):220. doi: 10.1186/bcr2921. Review.
STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity.
Able AA, Burrell JA, Stephens JM.
Biology (Basel). 2017 Mar 11;6(1). pii: E20. doi: 10.3390/biology6010020. Review.
Impact of prolactin receptor isoforms on reproduction.
Binart N, Bachelot A, Bouilly J.
Trends Endocrinol Metab. 2010 Jun;21(6):362-8. doi: 10.1016/j.tem.2010.01.008. Epub 2010 Feb 9. Review.
Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment.
Jiang M, Zhang WW, Liu P, Yu W, Liu T, Yu J.
Front Immunol. 2017 Feb 8;8:70. doi: 10.3389/fimmu.2017.00070. eCollection 2017. Review.
Hyperprolactinemia.
Majumdar A, Mangal NS.
J Hum Reprod Sci. 2013 Jul;6(3):168-75. doi: 10.4103/0974-1208.121400. Review.
Adapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.
Rider L, Diakonova M.
Mol Endocrinol. 2011 Jul;25(7):1231-43. doi: 10.1210/me.2011-0056. Epub 2011 May 12.

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Pathways

Prolactin Signaling

Description:

References:

Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone.

60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis.

A 60 kDa prolactin variant secreted by cervical cancer cells modulates apoptosis and cytokine production.

Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer.

STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity.

Impact of prolactin receptor isoforms on reproduction.

Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment.

Hyperprolactinemia.

Adapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.

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Pathways

Prolactin Signaling

Description:

References:

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