Pathways
Protein Acetylation and Deacetylation
Description:
Eukaryotic transcription is a highly regulated process, and acetylation plays a major role in this regulation. Acetylation can occur on histones, DNA-binding TF (Transcription Factors), acetylases, nuclear import factors, non-nuclear proteins (Alpha-tubulin) and proteins that shuttle from the nucleus to the cytoplasm, such as the Importin-Alpha family of nuclear import factors. Acetylation can modify the recognition of DNA, the stability of proteins and the interaction between proteins. They regulate different cellular proces...
References:
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Mechanisms of transcription factor acetylation and consequences in hearts.
Biochim Biophys Acta. 2016 Dec;1862(12):2221-2231. doi: 10.1016/j.bbadis.2016.08.011. Epub 2016 Aug 17. Review. -
Simple histone acetylation plays a complex role in the regulation of gene expression.
Brief Funct Genomic Proteomic. 2006 Sep;5(3):190-208. Review. -
Transcription regulation by the Mediator complex.
Nat Rev Mol Cell Biol. 2018 Apr;19(4):262-274. doi: 10.1038/nrm.2017.115. Epub 2017 Dec 6. Review. -
Erasers of histone acetylation: the histone deacetylase enzymes.
Cold Spring Harb Perspect Biol. 2014 Apr 1;6(4):a018713. doi: 10.1101/cshperspect.a018713. Review.
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