Pathways
G-Protein Signaling through Tubby
Description:
The Tubby protein is the founding member of a multigene protein family that plays an important role in maintenance and function of neuronal cells during development and post-differentiation. Currently, four Tubby gene family members (TUB, TULP1, TULP2 and TULP3) have been identified, which are conserved among different species of mammals (Ref.1). Besides, Tubby-like proteins are also found in other multicellular organisms including plants. These proteins feature a characteristic "Tubby domain" of approximately 260 a...
References:
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TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
Genes Dev. 2010 Oct 1;24(19):2180-93. doi: 10.1101/gad.1966210. -
Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases.
Proc Natl Acad Sci U S A 1997 Apr 1;94(7):3128-33. -
The tubby family proteins.
Genome Biol. 2011 Jun 28;12(6):225. doi: 10.1186/gb-2011-12-6-225. Review. -
Pharmacology of signaling induced by dopamine D(1)-like receptor activation.
Pharmacol Ther. 2010 Oct;128(1):37-60. doi: 10.1016/j.pharmthera.2010.05.003. Epub 2010 Jun 12. Review.
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