Pathways
PTEN Pathway
Description:
Phosphatase and tensin homolog deleted from chromosome 10 (PTEN) is a tumor suppressor protein, that is linked to AKT signaling, critically controlling proliferation, survival, migration, energy metabolism and cellular architecture in hematopoietic cells. PTEN is a dual-specificity protein phosphatase and an inositol phospholipid phosphatase that dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3), thus producing phosphatidylinositol 4,5-bisphosphate (PIP2) and thereby negatively regulating oncogenic and nononcogeni...
References:
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PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.
Blood. 2013 Jun 27;121(26):5208-17. doi: 10.1182/blood-2012-10-462887. Epub 2013 May 10. -
PTEN and the PI3-kinase pathway in cancer.
Annu Rev Pathol. 2009;4:127-50. doi: 10.1146/annurev.pathol.4.110807.092311. Review. -
The PTEN tumor suppressor gene and its role in lymphoma pathogenesis.
Aging (Albany NY). 2015 Dec;7(12):1032-49. Review. -
Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN.
Int J Oncol. 2011 Mar;38(3):823-31. doi: 10.3892/ijo.2010.893. Epub 2010 Dec 30.
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