Pathways
Ran Pathway
Description:
Ran is a member of the Ras family of small GTPases. The Ran subgroup is represented by its lone member, Ran, that is distinguished from Ras GTPases by its lipid modification and atypical subcellular localization. Unlike most other Ras-related proteins, Ran is not modified to bind to cell membranes. Instead, Ran protein is localized throughout the cell, where it is concentrated primarily in the nucleus (Ref.1). Ran is regulated by a cytosolic RanGAP1 (Ran GTPase–Activating Protein-1) and by a RanGEF (Chromatin-Bound Gu...
References:
-
A New Role for Ran in Ensuring Precise Duplication of Chromosomal DNA.
Cell. 2003 Apr 4;113(1):2-4. -
The RanGTP Pathway: From Nucleo-Cytoplasmic Transport to Spindle Assembly and Beyond.
Front Cell Dev Biol. 2016 Jan 11;3:82. doi: 10.3389/fcell.2015.00082. eCollection 2015. Review. -
RanGTP mediates nuclear pore complex assembly.
Nature. 2003 Aug 7;424(6949):689-94. -
Components and regulation of nuclear transport processes.
FEBS J. 2015 Feb;282(3):445-62. doi: 10.1111/febs.13163. Epub 2014 Dec 22. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions