Pathways
Ran Pathway
Description:
Ran is a member of the Ras family of small GTPases. The Ran subgroup is represented by its lone member, Ran, that is distinguished from Ras GTPases by its lipid modification and atypical subcellular localization. Unlike most other Ras-related proteins, Ran is not modified to bind to cell membranes. Instead, Ran protein is localized throughout the cell, where it is concentrated primarily in the nucleus (Ref.1). Ran is regulate[...]
References:
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A New Role for Ran in Ensuring Precise Duplication of Chromosomal DNA.
Cell. 2003 Apr 4;113(1):2-4. -
The RanGTP Pathway: From Nucleo-Cytoplasmic Transport to Spindle Assembly and Beyond.
Front Cell Dev Biol. 2016 Jan 11;3:82. doi: 10.3389/fcell.2015.00082. eCollection 2015. Review. -
RanGTP mediates nuclear pore complex assembly.
Nature. 2003 Aug 7;424(6949):689-94. -
Components and regulation of nuclear transport processes.
FEBS J. 2015 Feb;282(3):445-62. doi: 10.1111/febs.13163. Epub 2014 Dec 22. Review. -
The mammalian Mog1 protein is a guanine nucleotide release factor for Ran.
J Biol Chem. 2000 Jul 28;275(30):23175-80. -
Function of nuclear transport factor 2 and Ran in the 20E signal transduction pathway in the cotton bollworm, Helicoverpa armigera.
BMC Cell Biol. 2010 Jan 2;11:1. doi: 10.1186/1471-2121-11-1.
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