Pathways
RANK Pathway
Description:
Bone remodeling and homeostasis is an essential function that regulates skeletal integrity throughout adult life in higher vertebrates and mammals. The structural and metabolic integrity of bone is maintained through the dynamic process of bone remodeling that results from the coordinate action of bone resorption by osteoclasts and the formation of new bone by osteoblasts. Regulation of bone remodeling occurs through multiple mechanisms that ultimately converge on the interaction of osteoclasts or their precursors with osteob...
References:
-
Bone remodelling at a glance.
J Cell Sci. 2011 Apr 1;124(Pt 7):991-8. -
Osteoblast physiology in normal and pathological conditions.
Cell Tissue Res. 2011 Feb;343(2):289-302. Epub 2010 Dec 1. -
Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and Metastasis.
Clin Cancer Res. 2012 Jan 15;18(2):326-35. Epub 2011 Oct 26. -
The skeleton: a multi-functional complex organ: the role of key signalling pathways in osteoclast differentiation and in bone resorption.
J Endocrinol. 2011 Nov;211(2):131-43. doi: 10.1530/JOE-11-0212. Epub 2011 Sep 8.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions