Pathways
RANK Signaling in Osteoclasts
Description:
TNF (Tumor Necrosis Factor) and TNFR (Tumor Necrosis Factor Receptor) family proteins play important roles in the control of cell death, proliferation, autoimmunity, the function of immune cells, or the organogenesis of lymphoid organs. Recently, novel members of this large family have been identified that have critical functions in immunity and that couple lymphoid cells with other organ systems such as bone remodeling and mammary gland formation in pregnancy. Bone remodeling results from the coordinate action of osteoclasts an...
References:
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Cellular and molecular mechanisms of bone remodeling.
J Biol Chem. 2010 Aug 13;285(33):25103-8. Epub 2010 May 25. -
The mechanism of osteoclast differentiation induced by IL-1.
J Immunol. 2009 Aug 1;183(3):1862-70. Epub 2009 Jul 8. -
Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis.
Expert Opin Ther Targets. 2010 Sep;14(9):923-34. -
Crosstalk in NF-kB signaling pathways.
Nat Immunol. 2011 Jul 19;12(8):695-708. doi: 10.1038/ni.2065.
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