Pathways
Rap1 Pathway
Description:
Rap1 (Krev-1/smg p21), a small-molecular-weight GTP-binding protein that belongs to the Ras-like superfamily of GTPases, is involved in signal transduction cascades. It is highly homologous to Ras but it is down regulated by its own set of GAPs (GTPase-Activating Proteins). Rap1 is implicated in the regulation of a variety of cellular processes including the control of platelet activation, T-cell anergy, B-Cell activation, and neuronal differentiation. Very recently, Rap was shown to be involved in the control of cell adhes...
References:
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The Many Faces of Rap1 GTPase.
Int J Mol Sci. 2018;19(10):2848. -
The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA.
Sci Rep. 2013 Oct 23;3:3032. doi: 10.1038/srep03032. -
RAS Proteins and Their Regulators in Human Disease.
Cell. 2017 Jun 29;170(1):17-33. doi: 10.1016/j.cell.2017.06.009. -
Antigen receptors rap to integrin receptors.
Nat Immunol. 2002 Mar;3(3):212-3.
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