Pathways
RAR-Alpha-PML Fusion During APL
Description:
AMLs (Acute Myeloid Leukemias) are characterized with chromosomal translocations resulting in the formation of fusion proteins. Understanding PML (Acute Promyelocytic Leukemia Inducer) function has become an area of intense research because of its involvement in the pathogenesis of APL (Acute Promyelocytic Leukemia), a distinct subtype of Myeloid Leukemia. In the vast majority of APL case studies, the PML gene (on Chromosome-15) fuses to the RAR-Alpha gene (Retinoic Acid Receptor-Alpha) (on Chromo...
References:
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Is PML a Tumor Suppressor?
Front Oncol. 2013 Jul 9;3:174. doi: 10.3389/fonc.2013.00174. eCollection 2013. -
Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene.
Cancers (Basel). 2020 Mar 8;12(3). pii: E624. doi: 10.3390/cancers12030624. Review. -
Acute promyelocytic leukemia (APL): a review of the literature.
Oncotarget. 2020 Mar 17;11(11):992-1003. doi: 10.18632/oncotarget.27513. eCollection 2020 Mar 17. Review. -
All-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expression.
Mol Med Rep. 2015 Jul;12(1):210-8. doi: 10.3892/mmr.2015.3423. Epub 2015 Mar 4.
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