Pathways
Ras Pathway
Description:
Ras is a membrane-associated guanine nucleotide-binding protein that is normally activated in response to the binding of extracellular signals, such as growth factors, RTKs (Receptor Tyrosine Kinases), TCR (T-Cell Receptors) and PMA (Phorbol-12 Myristate-13 Acetate). Ras signaling affects many cellular functions, which includes cell proliferation, apoptosis, migration, fate specification, and differentiation. Ras acts as a binary signal switch cycling between ON and OFF states, which are characterized in terms of a small mole...
References:
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Role of H-Ras/ERK signaling in carbon nanotube-induced neoplastic-like transformation of human mesothelial cells.
Front Physiol. 2014 Jun 12;5:222. doi: 10.3389/fphys.2014.00222. eCollection 2014. -
Crosstalk between PI3 kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK pathways downstream PDGF receptor.
Cell Physiol Biochem. 2013;31(6):905-13. doi: 10.1159/000350108. Epub 2013 Jun 17. -
Rho GTPases, oxidation, and cell redox control.
Small GTPases. 2014;5:e28579. doi: 10.4161/sgtp.28579. Epub 2014 May 8. Review. -
Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.
Biochim Biophys Acta. 2014 Dec;1843(12):2976-2988. doi: 10.1016/j.bbamcr.2014.09.004. Epub 2014 Sep 16. Review.
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