Pathways
Reelin Pathway
Description:
Reelin is a large extracellular glycoprotein involved in the development of architectonic patterns, particularly in the cerebral cortex and hippocampus, where primarily Cajal-Retzius cells synthesize it The Reelin signaling pathway controls neuronal migration and positioning in central nervous system (CNS) development, as well as synaptic plasticity and memory (Ref.1). Reelin is localized to chromosome 7 in human with serine protease activity containing 3461 amino acids. It contains a signal...
References:
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Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3.
J Neurosci. 2009 Jan 7;29(1):288-99. doi: 10.1523/JNEUROSCI.2934-08.2009. -
New Insights into Reelin-Mediated Signaling Pathways.
Front Cell Neurosci. 2016 May 9;10:122. doi: 10.3389/fncel.2016.00122. -
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
J Biol Chem. 2017 Jan 27;292(4):1330-1338. doi: 10.1074/jbc.R116.766782. Epub 2016 Dec 19. -
The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.
J Lipid Res. 2017 Jun;58(6):1036-1043. doi: 10.1194/jlr.R075507. Epub 2017 Mar 14.
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