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Reelin Pathway


Reelin is a large extracellular glycoprotein involved in the development of architectonic patterns, particularly in the cerebral cortex and hippocampus, where primarily Cajal-Retzius cells synthesize it The Reelin signaling pathway controls neuronal migration and positioning in central nervous system (CNS) development, as well as synaptic plasticity and memory (Ref.1).  Reelin is localized to chromosome 7 in human with serine protease activity containing 3461 amino acids. It contains a signal...




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