Pathways
Regulation of EIF4 and p70S6K
Description:
Protein synthesis regulation in eukaryotes is important for the modulation of gene expression. The process of mRNA translation/protein synthesis is generally initiated by eukaryotic initiation factors (eIFs), which along with p70S6K play critical roles in translational regulation (Ref.1). During mRNA translation, eukaryotic initiation factor 4E (eIF4E) (the m7GTP cap-binding protein) binds to eIF4G (a scaffolding subunit) and eIF4A (an ATP-dependent RNA helicase) to form active eIF4F complex. eIF4F comp...
References:
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Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP.
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7545-50. doi: 10.1073/pnas.1605451113. Epub 2016 Jun 16. -
mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions.
Mol Biol Int. 2014;2014:686984. doi: 10.1155/2014/686984. Epub 2014 Nov 20. -
Signaling Pathways Involved in the Regulation of mRNA Translation.
Mol Cell Biol. 2018 May 29;38(12):e00070-18. doi: 10.1128/MCB.00070-18. -
Mnk kinase pathway: Cellular functions and biological outcomes.
World J Biol Chem. 2014 Aug 26;5(3):321-33. doi: 10.4331/wjbc.v5.i3.321.
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