Pathways
Relaxin Pathway
Description:
Relaxin is a polypeptide hormone that is secreted by the corpus luteum, into the circulation during the menstrual cycle and throughout pregnancy. During the cycle, it stimulates blood vessel growth in the endometrial lining of the uterus during the midluteal phase; coincident with the temporal window during which embryonic implantation occurs. If conception occurs, Relaxin levels rise and remain relatively constant during the entire gestational period (Ref.1). Relaxin is best known for its connect...
References:
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Anti-fibrotic actions of relaxin.
Br J Pharmacol. 2017 May;174(10):962-976. doi: 10.1111/bph.13529. Epub 2016 Jul 7. -
Cardioprotective actions of relaxin.
Mol Cell Endocrinol. 2019 May 1;487:45-53. doi: 10.1016/j.mce.2018.12.016. Epub 2019 Jan 6. -
Heart Disease and Relaxin: New Actions for an Old Hormone.
Trends Endocrinol Metab. 2018 May;29(5):338-348. doi: 10.1016/j.tem.2018.02.008. Epub 2018 Mar 8. -
Membrane receptors: structure and function of the relaxin family peptide receptors.
Mol Cell Endocrinol. 2010 May 14;320(1-2):1-15. doi: 10.1016/j.mce.2010.02.003. Epub 2010 Feb 6.
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