Pathways
Remodeling of Adherens Junctions
Description:
The intercellular Adherens Junctions (AJs) are specialized sub-apical structures that function as principle mediators of cell-cell adhesion. Their disassembly correlates with a loss of cell-cell contact and an acquisition of migratory potential. The Adherens Junctions have a crucial role both as sensors of extracellular stimuli and in regulating the dynamics of epithelial cell sheets or with neighboring cells. Cadherins, the Type-I transmembrane proteins of the Adherens Junctions, are principally responsible for homotypic c...
References:
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Dynamics of Adherens Junctions in Epithelial Establishment, Maintenance, and Remodeling.
J Cell Biol. 2011 Mar 21;192(6):907-17. doi: 10.1083/jcb.201009141. -
Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin.
Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3):a029140. doi: 10.1101/cshperspect.a029140. -
E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis.
Cell Commun Adhes. 2011 Dec;18(6):133-43. doi: 10.3109/15419061.2011.636465. Epub 2011 Dec 19. -
Biological influence of Hakai in cancer: a 10-year review.
Cancer Metastasis Rev. 2012 Jun;31(1-2):375-86. doi: 10.1007/s10555-012-9348-x.
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