Pathways
Repair of 8-OxoG by HOGG1
Description:
8-oxo-7,8-dihydroguanine (8-oxoG) is a pre-mutagenic DNA lesion that is formed by the oxidation of guanine. Reactive oxygen species (ROS) that is primarily responsible for the damage of guanine is produced as a result of several endogenous processes or environmental agents. ROS can cause damage to cellular macromolecules like proteins, lipids and nucleic acids. Proteins, proteins, lipids and RNA having oxidative damage are generally degraded and recycled, whereas DNA lesions like 8-oxoG need to be repaired to maintain genom...
References:
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8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions.
Redox Biol. 2018 Apr;14:669-678. doi: 10.1016/j.redox.2017.11.008. Epub 2017 Nov 10. -
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.
J Clin Invest. 2012 Dec;122(12):4344-61. doi: 10.1172/JCI65053. Epub 2012 Nov 12. -
Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway.
J Immunol. 2014 Nov 1;193(9):4643-53. doi: 10.4049/jimmunol.1401625. Epub 2014 Sep 29. -
Overview of base excision repair biochemistry.
Curr Mol Pharmacol. 2012 Jan;5(1):3-13. doi: 10.2174/1874467211205010003.
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