Repair of Thymine Dimers in E. coli

Description:

UV radiation induces two of the most abundant mutagenic and cytotoxic DNA lesions such as CPD (Cyclobutane-Pyrimidine Dimers) or 6-4PPs (6-4 Pyrimidine Pyrimidone). The most common covalently linked adjoining pyrimidines are TT(Thymine dimers), T-C (Thymine-Cytosine dimers) and C-C (Cytosine-Cytosine dimers). T-T dimers cause kinks in the DNA strand that prevent both replication and transcription of that part of the DNA. Because they block DNA replication (and therefore prevent cells from reproducing), T-T ...

References:

The role of Escherichia coli UvrB in nucleotide excision repair.
Seeley TW, Grossman L.
J Biol Chem. 1990 May 5; 265(13): 7158-65.
UV-induced DNA damage and repair: a review.
Sinha RP, Hader DP.
Photochem Photobiol Sci. 2002 Apr; 1(4): 225-36. Review.
The isomerization of the UvrB-DNA preincision complex couples the UvrB and UvrC activities.
Delagoutte E, Fuchs RP, Bertrand-Burggraf E.
J Mol Biol. 2002 Jun 28; 320(1):73-84.

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Repair of Thymine Dimers in E. coli

Description:

References:

The role of Escherichia coli UvrB in nucleotide excision repair.

UV-induced DNA damage and repair: a review.

The isomerization of the UvrB-DNA preincision complex couples the UvrB and UvrC activities.

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Repair of Thymine Dimers in E. coli

Description:

References:

The role of Escherichia coli UvrB in nucleotide excision repair.

UV-induced DNA damage and repair: a review.

The isomerization of the UvrB-DNA preincision complex couples the UvrB and UvrC activities.

Databases

Tools

Institutional License

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