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Repair of Uracil Residues


The integrity and accuracy of the DNA is of critical importance to the cell, but the organization of DNA into chromatin in eukaryotic cells afford little protection against formation of DNA base damage generated spontaneously through hydrolysis, since DNA remains hydrated in chromatin. Two frequently occurring hydrolytic reactions are depurination to produce non-coding abasic sites, and deamination of cytosine (C) to uracil (U)[...]




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