Pathways
RHOGDI Pathway
Description:
The Rho family of small GTPase proteins comprises CDC42 (Cell Division Cycle-42), Rac, and Rho. Proteins of the Rho/Rac subfamily (Rho proteins) of small GTP-binding proteins function as molecular switches that regulate a multitude of biological processes including cell proliferation, apoptosis, differentiation, migration, cytoskeletal reorganization, and membrane trafficking. Like most of the Ras-related proteins, Rho GTPases cycle between an inactive GDP-bound conformation and an active GTP- bound conformation. Cycling betw...
References:
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Rho GTPases: Regulation and roles in cancer cell biology.
Small GTPases. 2016 Oct;7(4):207-221. doi: 10.1080/21541248.2016.1232583. Epub 2016 Sep 14. -
The 'invisible hand': regulation of RHO GTPases by RHOGDIs.
Nat Rev Mol Cell Biol. 2011 Jul 22;12(8):493-504. doi: 10.1038/nrm3153. -
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.
BMC Syst Biol. 2015 Jan 28;9:3. doi: 10.1186/s12918-015-0143-5. -
Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease.
Cells. 2019 Apr 29;8(5):396. doi: 10.3390/cells8050396.
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