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Pathways

RNAi Pathway

Description:

RNAi (RNA interference) is broadly defined as a gene silencing pathway that is triggered by dsRNA (double-stranded RNA). The dsRNA trigger can be supplied exogenously, as an experimental tool, or can derive from the genome. RNAi involves a number of steps from biogenesis of the trigger RNA, processing of dsRNA to small RNAs and formation of an effector complex containing the small RNA which goes on to guide mRNA cleavage, translational repression and/or chromatin modifications in a sequence-specific manner. Two types of small...

References:

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