Pathways
RNAi Pathway
Description:
RNAi (RNA interference) is broadly defined as a gene silencing pathway that is triggered by dsRNA (double-stranded RNA). The dsRNA trigger can be supplied exogenously, as an experimental tool, or can derive from the genome. RNAi involves a number of steps from biogenesis of the trigger RNA, processing of dsRNA to small RNAs and formation of an effector complex containing the small RNA which goes on to guide mRNA cleavage, translational repression and/or chromatin modifications in a sequence-specific manner. Two types of small...
References:
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RNA-based mechanisms regulating host-virus interactions.
Immunol Rev. 2013 May;253(1):97-111. doi: 10.1111/imr.12053. -
Origins and Mechanisms of miRNAs and siRNAs.
Cell. 2009 Feb 20;136(4):642-55. doi: 10.1016/j.cell.2009.01.035. -
siRNA and miRNA processing: new functions for Cajal bodies.
Nat Rev Genet. 2012 Mar 13;13(4):271-82. doi: 10.1038/nrg3162. Epub 2008 Mar 11. Review. -
RNA interference pathways in filamentous fungi.
Cell Mol Life Sci. 2010 Nov;67(22):3849-63. doi: 10.1007/s00018-010-0471-y. Epub 2010 Aug 1.
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