Pathways
Role of TNF in Cancer
Description:
Tumor necrosis factor superfamily (TNFSF) comprises a group of cytokine ligands and their cognate receptors that are essential for the activation, proliferation, differentiation, and effector function of immune cells. TNF superfamily contains about 19 ligands and 29 receptors in humans which are implicated in many autoimmune and inflammatory diseases including cancer. Among the members, tumor necrosis factor-alpha (TNF-alpha) is one of the most extensively studied inflammatory cytokines involved in apoptosis regulation, host ...
References:
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Editorial: The Tumor Necrosis Factor Superfamily: An Increasing Role in Breast Cancer.
Front Oncol. 2020 Dec 22;10:622588. doi: 10.3389/fonc.2020.622588. -
The role of TNF superfamily members in T-cell function and diseases.
Nat Rev Immunol. 2009 Apr;9(4):271-85. doi: 10.1038/nri2526. -
Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.
Oncotarget. 2017 Apr 6;8(35):58338-58352. doi: 10.18632/oncotarget.16873. -
Tumor necrosis factor receptor 2: its contribution to acute cellular rejection and clear cell renal carcinoma.
Biomed Res Int. 2013;2013:821310. doi: 10.1155/2013/821310. Epub 2013 Nov 17.
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