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Role of TNF in Cancer


Tumor necrosis factor superfamily (TNFSF) comprises a group of cytokine ligands and their cognate receptors that are essential for the activation, proliferation, differentiation, and effector function of immune cells. TNF superfamily contains about 19 ligands and 29 receptors in humans which are implicated in many autoimmune and inflammatory diseases including cancer. Among the members, tumor necrosis factor-alpha (TNF-alpha) is one of the most extensively studied inflammatory cytokines involved in apoptosis regulation, host ...




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