Pathways
Salmonella Infection
Description:
Phagocytic cells are a critical line of defense against infection. The ability of a pathogen to survive and even replicate within phagocytic cells is a potent method of evading the defense mechanisms of the host. A number of pathogens survive within macrophages after phagocytosis and this contributes to their virulence. Salmonella is one of these pathogens. Salmonella spp are Gram-negative bacteria capable of infecting a wide range of host species, including humans, domesticated and wild mammals, reptiles, birds and insects. ...
References:
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Salmonella Virulence and Immune Escape.
Microorganisms. 2020 Mar 13;8(3):407. doi: 10.3390/microorganisms8030407. -
Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells.
Annu Rev Microbiol. 2014;68:415-38. doi: 10.1146/annurev-micro-092412-155725. Epub 2014 Jun 18. -
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Front Cell Infect Microbiol. 2017 Aug 9;7:348. doi: 10.3389/fcimb.2017.00348. -
Salmonella enterica serovar typhimurium invades fibroblasts by multiple routes differing from the entry into epithelial cells.
Infect Immun. 2010 Jun;78(6):2700-13. doi: 10.1128/IAI.01389-09. Epub 2010 Apr 5.
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