Pathways
SARS CoV Replication Mechanism
Description:
SARS (Severe Acute Respiratory Syndrome) is a newly emerged infection in humans characterized by fever and pneumonia. This disease may progress rapidly to ARDS (Acute Respiratory Distress Syndrome) with considerable morbidity and mortality. It was first identified in the Guandong Province of China in November 2002, and a major outbreak occurred in Hong Kong in March 2003 (Ref.1). Probable cases have been reported in 31 countries, with extensive ongoing transmission in Taiwan and China, continuing transmission...
References:
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Severe Acute Respiratory Syndrome: Historical, Epidemiologic, and Clinical Features.
Infect Dis Clin North Am. 2019;33(4):869-889. doi:10.1016/j.idc.2019.07.001 -
SARS coronavirus: a new challenge for prevention and therapy.
J Clin Invest. 2003 Jun; 111(11): 1605-9. Review. No abstract available. -
Mechanisms of coronavirus cell entry mediated by the viral spike protein.
Viruses. 2012;4(6):1011-1033. doi:10.3390/v4061011 -
Human Coronaviruses: A Review of Virus-Host Interactions.
Diseases. 2016;4(3):26. Published 2016 Jul 25. doi:10.3390/diseases4030026
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