Pathways
Sertoli-Sertoli Cell Junction Dynamics
Description:
The Blood-Testes Barrier (abbreviated as BTB) acts as a physical barrier between the blood vessels and the seminiferous tubules of the testes. This barrier is formed by tight and adherens connections between the Sertoli cells, which are sustentacular cells (supporting cells) of the seminiferous tubules, and nourish the spermatogonia (Ref.1). In the testes, tight and adherens junctions are dynamically remodeled to allow the movement of post-meiotic germ cells across the seminiferous epithelium and the timely release of spermatids...
References:
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The blood-testis barrier and its implications for male contraception.
Pharmacol Rev. 2012 Jan;64(1):16-64. doi: 10.1124/pr.110.002790. Epub 2011 Oct 28. Review. -
Phosphatase regulation of intercellular junctions.
Tissue Barriers. 2013 Dec 1;1(5):e26713. doi: 10.4161/tisb.26713. Epub 2013 Oct 10. Review. -
p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression.
Prog Mol Biol Transl Sci. 2013;116:409-32. doi: 10.1016/B978-0-12-394311-8.00018-2. Review. -
Transcriptional regulation of cell adhesion at the blood-testis barrier and spermatogenesis in the testis.
Adv Exp Med Biol. 2012;763:281-94. Review.
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