T cell responses against tumors require the recognition of specific peptides derived from tumor antigens in association with MIC (MHC Class I Molecules) by CD81 T cells expressing TCRs (T Cell Receptors). Such response generates intracellular antigen processing which are highly selective and binds only to some of the numerous polymorphic MHC class I molecules and often-impaired expression of MHC class I on tumor cells. Human gamma delta T cells are MICA (MHC-Class-Ipolypeptide-Related sequence-A) and MICB (MHC-Class-Ipolype...
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