T cell responses against tumors require the recognition of specific peptides derived from tumor antigens in association with MIC (MHC Class I Molecules) by CD81 T cells expressing TCRs (T Cell Receptors). Such response generates intracellular antigen processing which are highly selective and binds only to some of the numerous polymorphic MHC class I molecules and often-impaired expression of MHC class I on[...]
Kriegeskorte AK, Gebhardt FE, Porcellini S, Schiemann M, Stemberger C, Franz TJ, Huster KM, Carayannopoulos LN, Yokoyama WM, Colonna M, Siccardi AG, Bauer S, Busch DH. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11805-10. Epub 2005 Aug 9.