Pathways
Shigella Invasion
Description:
Bacterial pathogens possess highly specialized adaptive processes that enable their penetration of the host intestinal epithelium and cause disease. Once bound to the epithelial surface, bacteria may colonize and establish a permanent residence in the gut. Some Gram-negative pathogenic bacteria have acquired sophisticated 'molecular syringes', such as Type-III or Type-IV secretion systems, which are multisubunit molecular machines that span the bacterial and host membranes and translocate effectors directly into host ...
References:
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Bacterial Secretion Systems: An Overview.
Microbiol Spectr. 2016;4(1):10.1128/microbiolspec.VMBF-0012-2015. doi:10.1128/microbiolspec.VMBF-0012-2015 -
Actin cytoskeleton manipulation by effector proteins secreted by diarrheagenic Escherichia coli pathotypes.
Biomed Res Int. 2013;2013:374395. doi:10.1155/2013/374395 -
Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.
Clin Microbiol Rev. 2008;21(1):134-156. doi:10.1128/CMR.00032-07 -
Arp2/3-mediated actin-based motility: a tail of pathogen abuse.
Cell Host Microbe. 2013;14(3):242-255. doi:10.1016/j.chom.2013.08.011
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