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Sigma-1 Receptor and Neurodegenerative Disease


The ER (Endoplasmic Reticulum) is a crucial organelle involved in many functions. In the cell protein misfolding can results from genetic mutations affecting normal protein folding or malfunction of the cytosolic ER resident protein folding machinery. Many diseases result from misfolded protein that accumulates within the ER, where they generate a stressful condition referred to as ER stress. Cells counteract ER stress by activating a group of signaling pathways termed the UPR (Unfolded Protein Response) that coordinate a pot...




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