Pathways
Sigma-1 Receptor and Neurodegenerative Disease
Description:
The ER (Endoplasmic Reticulum) is a crucial organelle involved in many functions. In the cell protein misfolding can results from genetic mutations affecting normal protein folding or malfunction of the cytosolic ER resident protein folding machinery. Many diseases result from misfolded protein that accumulates within the ER, where they generate a stressful condition referred to as ER stress. Cells counteract ER stress by activating a group of signaling pathways termed the UPR (Unfolded Protein Response) that coordinate a pot...
References:
-
The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance.
Front Mol Neurosci. 2017 Jun 16;10:187. doi: 10.3389/fnmol.2017.00187. -
Role of sigma-1 receptors in neurodegenerative diseases.
J Pharmacol Sci. 2015 Jan;127(1):17-29. doi: 10.1016/j.jphs.2014.12.005. Epub 2014 Dec 11. -
Sigma receptors [σRs]: biology in normal and diseased states.
J Recept Signal Transduct Res. 2016 Aug;36(4):327-388. doi: 10.3109/10799893.2015.1015737. Epub 2015 Jun 9. -
The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases.
Curr Neuropharmacol. 2018;16(1):97-116. doi: 10.2174/1570159X15666170529104323.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions