Pathways
Signaling by SLIT
Description:
Neuronal growth cones in the developing nervous system are guided to their targets by attractive and repulsive guidance molecules, which include members of the Netrin, Semaphorin, Ephrin, and Slit protein families. Slit is a ~200 KD secretory protein originally shown to be expressed by neurons and glial cells. Slit was originally identified in Drosophila as an extracellular cue to guide axon pathfinding, to promote axon branching, and to control neuronal migration (Ref.1).
Mammalian Slit consists ...
References:
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Mechanisms and molecules of neuronal wiring: a primer.
Cold Spring Harb Perspect Biol. 2011;3(6):a001727. Published 2011 Jun 1. doi:10.1101/cshperspect.a001727 -
Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system.
PLoS One. 2017;12(2):e0172736. Published 2017 Feb 24. doi:10.1371/journal.pone.0172736 -
Changes in mRNA of Slit-Robo GTPase-activating protein 2 following facial nerve transection.
Brain Res Mol Brain Res. 2004 Apr 7; 123(1-2):76-80. -
Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.
Curr Opin Genet Dev. 2002 Oct; 12(5):583-91. Review.
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