Pathways
Signaling in Gap Junctions
Description:
Gap Junction (GJ) channels span two plasma membranes and are formed by the alignment of two hemichannels, each consisting of an oligomer of structural subunit proteins, called Cxs (Connexins). These junctional proteins constitute a multigene family whose members are distinguished according to their predicted molecular weight in kilodaltons. A Connexin structure consists of two extracellular loops (EL), four membrane-spanning domains (TM), one cytoplasmic loop (CL), one N-terminal tail (NT), and one C-terminal tail (CT) (Ref...
References:
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Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision.
BMC Cell Biol. 2016;17 Suppl 1(Suppl 1):11. Published 2016 May 24. doi:10.1186/s12860-016-0099-3 -
Connexins and their channels in cell growth and cell death.
Cell Signal. 2006 May;18(5):592-600. -
Expression and functions of neuronal gap junctions.
Nat. Rev. Neurosci. 2005 Mar;6(3):191-200. -
Regulation of connexin expression.
Biochim. Biophys. Acta. 2005 Dec 20;1719(1-2):6-23.
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