Pathways
Signaling Involved in Cardiac Hypertrophy
Description:
Myocardial hypertrophy is an adaptational response of the heart to increased work load, but it is also associated with a high risk of cardiac mortality due to its established role in the development of cardiac failure, one of the leading causes of death in developed countries (Ref.1). The hypertrophic growth of the myocardium is initiated by a wide array of endocrine, paracrine, and autocrine growth factors in response to biomechanical stress, increased workload, injury, or, intrinsic defects in contractile performance. Car...
References:
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From Left Ventricular Hypertrophy to Dysfunction and Failure.
Circ J. 2016;80(3):555-564. doi:10.1253/circj.CJ-16-0062 -
The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.
Br J Pharmacol. 2013;168(2):296-317. doi:10.1111/j.1476-5381.2012.02195.x -
Cytoplasmic signaling pathways that regulate cardiac hypertrophy.
Annu Rev Physiol. 2001; 63:391-426. Review. -
Cardiac hypertrophy: the good, the bad, and the ugly.
Annu Rev Physiol. 2003; 65:45-79. Epub 2003 Jan 09. Review.
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