Pathways
siRNA Pathway in Drosophila and S.pombe
Description:
siRNAs (Small interfering RNAs) have gained much attention for their powerful ability to suppress gene expression. Introduction of dsRNA (double-stranded RNA), that are homologous in sequence to a gene, has proven to suppress that gene’s expression through a process known as RNAi (RNA interference). The basic mechanism behind RNAi is the breaking of a dsRNA matching a specific gene sequence into siRNA. These siRNAs are 21–23nt dsRNA duplexes with symmetric 2–3nt 3' overhangs and 5'-phosphate and 3&...
References:
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Molecular Mechanisms and Biological Functions of siRNA.
Int J Biomed Sci. 2017 Jun;13(2):48-57. -
Ribonucleic acid interference induced gene knockdown.
J Indian Soc Periodontol. 2013 Jul;17(4):417-22. doi: 10.4103/0972-124X.118309. -
Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation.
Mol Cell. 2016 Jul 21;63(2):191-205. doi: 10.1016/j.molcel.2016.05.039. Epub 2016 Jul 7. -
RNA Silencing in Plants: Mechanisms, Technologies and Applications in Horticultural Crops. Curr Genomics.
Curr Genomics. 2016;17(6):476-489.
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