Pathways
siRNA Pathway in Nematode and Mammal
Description:
Introduction of dsRNA (double-stranded RNA), that are homologous in sequence to a gene, has proven to suppress that gene’s expression through a process known as RNAi (RNA interference). The mechanism of RNAi involves the breaking of a dsRNA matching a specific gene sequence into siRNA (Small interfering RNAs). These siRNAs are 21–23nt dsRNA duplexes with symmetric 2–3nt 3' overhangs and 5'-phosphate and 3'-hydroxyl groups trigger the degradation of mRNA that match its sequence (Ref.1). Interfer...
References:
-
Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting.
RNA. 2007 Apr;13(4):431-56. doi: 10.1261/rna.459807. Epub 2007 Feb 28. -
Expanding small RNA interference.
Nat Biotechnol. 2002 May; 20(5): 446-8. No abstract available. -
New insights into siRNA amplification and RNAi.
RNA Biol. 2012 Aug;9(8):1045-9. doi: 10.4161/rna.21246. Epub 2012 Aug 1. -
MicroRNA: Biogenesis, Function and Role in Cancer.
Curr Genomics. 2010 Nov;11(7):537-61. doi: 10.2174/138920210793175895.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions