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siRNA Pathway in Nematode and Mammal


Introduction of dsRNA (double-stranded RNA), that are homologous in sequence to a gene, has proven to suppress that gene’s expression through a process known as RNAi (RNA interference). The mechanism of RNAi involves the breaking of a dsRNA matching a specific gene sequence into siRNA (Small interfering RNAs). These siRNAs are 21–23nt dsRNA duplexes with symmetric 2–3nt 3' overhangs and 5'-phosphate [...]




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