SOCS Pathway

Description:

Our immune system is largely controlled by the action of pleiotropic cytokines and growth factors, small secreted proteins, which bind to receptors on the surface of immune cells to initiate an appropriate physiological response. The cellular response to cytokines and growth factors is predominantly executed by intracellular proteins known as the Janus kinases (JAKs) and the signal transducers and activators of transcriptions (STATs). These kinases activated upon ligand binding causes the ph...

References:

Understanding SOCS protein specificity.
Linossi EM, Calleja DJ, Nicholson SE.
Growth Factors. 2018 Aug;36(3-4):104-117. doi: 10.1080/08977194.2018.1518324. Epub 2018 Oct 15.
Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease.
Durham GA, Williams JJL, Nasim MT, Palmer TM.
Trends Pharmacol Sci. 2019 May;40(5):298-308. doi: 10.1016/j.tips.2019.03.001. Epub 2019 Apr 2.
SOCS proteins, cytokine signalling and immune regulation.
Yoshimura A, Naka T, Kubo M.
Nat Rev Immunol. 2007 Jun;7(6):454-65. doi: 10.1038/nri2093. Epub 2007 May 18.
The Role of Elongin BC-Containing Ubiquitin Ligases.
Okumura F, Matsuzaki M, Nakatsukasa K, Kamura T.
Front Oncol. 2012 Feb 3;2:10. doi: 10.3389/fonc.2012.00010.

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Pathways

SOCS Pathway

Description:

References:

Understanding SOCS protein specificity.

Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease.

SOCS proteins, cytokine signalling and immune regulation.

The Role of Elongin BC-Containing Ubiquitin Ligases.

Databases

Tools

Institutional License

Pathways

SOCS Pathway

Description:

References:

Understanding SOCS protein specificity.

Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease.

SOCS proteins, cytokine signalling and immune regulation.

The Role of Elongin BC-Containing Ubiquitin Ligases.

Databases

Tools

Institutional License

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