SOS Repair in E. coli

Description:

All organisms are exposed to a multitude of DNA damaging agents ranging from UV (Ultraviolet) light to fungal metabolites, like Aflatoxin B1. Furthermore, DNA damaging agents, such as ROS (Reactive Oxygen Species), can be produced by cells themselves as metabolic byproducts and intermediates. Together, these agents pose a constant threat to an organism's genome. As a result, organisms have evolved a number of vitally important mechanisms to repair DNA damage in a high fidelity manner. They have also evolved systems (cel...

References:

Mechanisms of DNA damage, repair, and mutagenesis.
Chatterjee N, Walker GC.
Environ Mol Mutagen. 2017 Jun;58(5):235-263.
The SOS system: A complex and tightly regulated response to DNA damage.
Maslowska KH, Makiela-Dzbenska K, Fijalkowska IJ.
Environ Mol Mutagen. 2019 May;60(4):368-384.
A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V.
Patel M, Jiang Q, Woodgate R, Cox MM, Goodman MF.
Crit Rev Biochem Mol Biol. 2010 Jun;45(3):171-84.
Taylor MRG, Yeeles JTP.
Dynamics of Replication Fork Progression Following Helicase-Polymerase Uncoupling in Eukaryotes.
J Mol Biol. 2019 May 3;431(10):2040-2049.

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Pathways

SOS Repair in E. coli

Description:

References:

Mechanisms of DNA damage, repair, and mutagenesis.

The SOS system: A complex and tightly regulated response to DNA damage.

A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V.

Taylor MRG, Yeeles JTP.

Databases

Tools

Institutional License

Pathways

SOS Repair in E. coli

Description:

References:

Mechanisms of DNA damage, repair, and mutagenesis.

The SOS system: A complex and tightly regulated response to DNA damage.

A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V.

Taylor MRG, Yeeles JTP.

Databases

Tools

Institutional License

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