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Sphingolipid Metabolism and Apoptosis


The sphingolipids are primarily situated in the noncytoplasmic leaflet of cellular membranes contribute to the structural integrity and fluidity characteristics of cell membranes and signal transduction complexes. Ceramide sits at the hub of sphingolipid metabolism as the neutral, lipid building block for complex sphingolipids and glycosphingolipids, serving as a substrate for more than 11 different enzymes Ceramide is also a key intermediate for the biosynthesis of the major plasma membrane sphin...




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