Pathways
Sphingolipid Metabolism and Apoptosis
Description:
The sphingolipids are primarily situated in the noncytoplasmic leaflet of cellular membranes contribute to the structural integrity and fluidity characteristics of cell membranes and signal transduction complexes. Ceramide sits at the hub of sphingolipid metabolism as the neutral, lipid building block for complex sphingolipids and glycosphingolipids, serving as a substrate for more than 11 different enzymes Ceramide is also a key intermediate for the biosynthesis of the major plasma membrane sphin...
References:
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Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.
Traffic. 2015 Feb;16(2):101-22. doi: 10.1111/tra.12239. Epub 2014 Dec 16. -
Sphingolipid metabolism and drug resistance in ovarian cancer.
Cancer Drug Resist. 2018;1:181-197. doi: 10.20517/cdr.2018.06. Epub 2018 Sep 19. -
Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate.
Int J Mol Sci. 2015 Mar 5;16(3):5076-124. doi: 10.3390/ijms16035076. -
The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids.
FEMS Yeast Res. 2014 Feb;14(1):160-78. doi: 10.1111/1567-1364.12096. Epub 2013 Oct 14. Erratum in: FEMS Yeast Res. 2014 Sep;14(6):995.
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