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Spliceosomal Splicing Cycle


During the final step in formation of a mature, functional mRNA, the introns are removed and exons are spliced together. The discovery that introns are removed during splicing came from electron microscopy of RNA-DNA hybrids between adenovirus DNA and the mRNA encoding hexon, a major virion capsid protein. For short transcription units, RNA splicing usually follows cleavage and polyadenylation of the 3’ end of the primary transc[...]




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