SREBP Proteolysis

Description:

Cellular Lipid homeostasis in mammalian cells is regulated through the end-product feedback regulation of Lipid synthesis by a family of membrane-bound transcription factors designated SREBPs (Sterol Regulatory Element–Binding Proteins) that control the flux of cellular metabolites into the major Lipid pathways. The mammalian cell continuously adjusts its Sterol content by regulating levels of key Sterol synthetic enzymes and levels of Lipoprotein receptors that mediate uptake of Cholesterol-laden particles. Control is brought...

References:

Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.
Herman GE.
Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo.
Bennett MK, Toth JI, Osborne TF.
J Biol Chem. 2004 Sep 3;279(36):37360-7.
Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells.
Li N, Zhao F, Wei C, Liang M, Zhang N, Wang C, Li QZ, Gao XJ.
Int J Mol Sci. 2014 Sep 23;15(9):16998-7013. doi: 10.3390/ijms150916998.
Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulumrecycling of SREBP cleavage-activating protein (SCAP).
Shao W, Espenshade PJ.
J Biol Chem. 2014 Mar 14;289(11):7547-57. doi: 10.1074/jbc.M113.545699. Epub 2014 Jan 29.

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Pathways

SREBP Proteolysis

Description:

References:

Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.

Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo.

Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells.

Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulumrecycling of SREBP cleavage-activating protein (SCAP).

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Institutional License

Pathways

SREBP Proteolysis

Description:

References:

Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.

Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo.

Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells.

Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulumrecycling of SREBP cleavage-activating protein (SCAP).

Databases

Tools

Institutional License

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