Pathways
Steroidogenesis in X. laevis Ovary
Description:
Ovarian sex steroid production is essential for Follicular growth and subsequent Ovulation in Xenopus laevis. In the Xenopus ovary, Oocytes are arrested in an immature form in the Cell Cycle at Prophase-I boundary of the first meiotic cycle, and grow to their maximal size. Prophase-I arrest is terminated by specific signals, often Steroid Hormones, that cause release from Cell Cycle arrest and induce progression of the Meiotic Cell Cycles to an arrest point during the second Meiotic division, often at Metaphase-II. This...
References:
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Xenopus laevis ovarian CYP17 is a highly potent enzyme expressed exclusively in oocytes. Evidence that oocytes play a critical role in Xenopus ovarian androgen production.
J Biol Chem. 2003 Mar 14;278(11):9552-9. -
Steroids and oocyte maturation--a new look at an old story.
Mol Endocrinol. 2004 Apr;18(4):769-75. -
Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5.
J Biol Chem. 2005 Mar 18;280(11):10196-201. -
Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation.
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13728-33.
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