Pathways
SUMO Pathway
Description:
Covalent modifications of proteins, such as phosphorylation, acetylation and ubiquitylation, play an important role in most cellular processes because they can cause rapid changes in the activities of pre-existing proteins. This type of mechanism for regulating protein function is especially crucial in signal transduction pathways and in cell cycle. Posttranslational modifications (PTMs) by members of the ubiquitin family are covalent events that promote radical changes in the properties of modified proteins. Among all ubiqui...
References:
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Strategies to Identify Recognition Signals and Targets of SUMOylation.
Biochem Res Int. 2012; 2012:875148. doi: 10.1155/2012/875148. Epub 2012 Jul 1. -
SUMO: a history of modification.
Mol Cell. 2005 Apr 1; 18(1):1-12. Review. -
PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription.
Biochem Soc Trans. 2007 Dec; 35(Pt 6):1405-8. Review. -
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.
Nat Rev Mol Cell Biol. 2010 Dec; 11(12):861-71. doi: 10.1038/nrm3011. Review.
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