Pathways
Synthesis of Cardiolipin and Phosphatidylinositol
Description:
Phosphoglycerides such as phosphatidylethanolamine and phosphatidylserine are the major component of lipid bilayer membranes in which their detergent-like properties help to provide membranes the quality of self-assembly. Phosphatidylglycerol is a precursor in the synthesis of both cardiolipin and PI (Phosphatidylinositol). Cardiolipin is a unique dimeric phospholipid found in the heart and most mammalian tissues. This phospholipid is the only phospholipid localized primarily in the mitochondrial membrane of mammalian cells. ...
References:
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CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis.
Front Cell Dev Biol. 2020 Feb 7;8:63. doi: 10.3389/fcell.2020.00063. -
Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects.
Cells. 2019 Jul 16;8(7):728. doi: 10.3390/cells8070728. -
Mammalian cardiolipin biosynthesis.
Chem Phys Lipids. 2014 Apr;179:11-6. doi: 10.1016/j.chemphyslip.2013.10.001. Epub 2013 Oct 19. -
Distinct properties of the two isoforms of CDP-diacylglycerol synthase.
Biochemistry. 2014 Dec 2;53(47):7358-67. doi: 10.1021/bi501250m. Epub 2014 Nov 14.
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