Pathways
Synthesis of Pyrimidine Ribonucleotides
Description:
Synthesis of the Pyrimidines is less complex than that of the Purines, since the base is much simpler. Synthesis of Carbamoyl-P (Carbamoyl Phosphate) is the first reaction of Pyrimidine biosynthesis. Carbamoyl-P is formed from HCO3- (Bicarbonate) and the amide nitrogen of Glutamine by the cytosolic enzyme CPSase (Carbamoyl Phosphate Synthetase). This reaction consumes two molecules of ATP (Adenosine Monophosphate): One provides a phosphate group and the other energizes the reaction. Then condensation of Carbamoyl-P with Asp (...
References:
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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.
J Biol Chem. 2004 Aug 6;279(32):33035-8. doi: 10.1074/jbc.R400007200. Epub 2004 Apr 19. -
Orotate (orotic acid): An essential and versatile molecule.
Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):566-577. doi: 10.1080/15257770.2016.1147580. -
Metabolic regulation and overproduction of primary metabolites.
Microb Biotechnol. 2008 Jul;1(4):283-319. doi: 10.1111/j.1751-7915.2007.00015.x. -
Higher order structures in purine and pyrimidine metabolism.
J Struct Biol. 2017 Mar;197(3):354-364. doi: 10.1016/j.jsb.2017.01.003. Epub 2017 Jan 21.
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