Pathways
Systemic Lupus Erythematosus
Description:
SLE (Systemic lupus erythematosis) is a chronic autoimmune disease characterized by the production of autoantibodies and the deposition of immune complexes, affecting a wide range of organs. A complex interaction of genetics, environmental factors and hormones result in the breakdown of immune tolerance to “self” leading to damage and destruction of multiple organs, such as the skin, joints, kidneys, heart and brain. Both innate and adaptive immune systems are critically involved in the misguided immune response a...
References:
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Pathways leading to an immunological disease: systemic lupus erythematosus.
Rheumatology (Oxford). 2017 Apr 1;56(suppl_1):i55-i66. doi: 10.1093/rheumatology/kew427. Review. -
Systemic lupus erythematosus.
Nat Rev Dis Primers. 2016 Jun 16;2:16039. doi: 10.1038/nrdp.2016.39. Review. -
Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
Front Immunol. 2018 May 17;9:1088. doi: 10.3389/fimmu.2018.01088. eCollection 2018. Review. -
Neutrophil Extracellular Traps and Systemic Lupus Erythematosus.
J Clin Cell Immunol. 2013 Apr;4. pii: 139.
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