Pathways
Telomerase Components in Cell Signaling
Description:
The extended growth potential of cancer cells is critically dependent upon the maintenance of functional telomeres, which are specialized chromosomal DNA-protein structures in the terminal regions of eukaryotic chromosomes (Ref.1). In order to divide, a normal cell has to replicate the entire DNA in its chromosomes. But normal cells have difficulty in copying the last few bases on the telomere. As a result, the telomere shortens with each round of DNA replication and cell division and as a cell ages, the telomere keeps shorte...
References:
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Telomeres: Implications for Cancer Development.
Int J Mol Sci. 2018 Jan 19;19(1). pii: E294. doi: 10.3390/ijms19010294. Review. -
Telomere-regulating genes and the telomere interactome in familial cancers.
Mol Cancer Res. 2015 Feb;13(2):211-22. doi: 10.1158/1541-7786.MCR-14-0305. Epub 2014 Sep 22. Review. -
Telomere structure and telomerase in health and disease (review).
Int J Oncol. 2012 Nov;41(5):1561-9. doi: 10.3892/ijo.2012.1611. Epub 2012 Aug 29. Review. -
The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.
Nucleic Acids Res. 2015 Jun 23;43(11):5537-49. doi: 10.1093/nar/gkv406. Epub 2015 May 4.
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