Pathways
Telomere Extension by Telomerase
Description:
Unlimited replicative potential and widespread genomic disarray are among the most common characteristics exhibited by human cancer cells. Although several distinct molecular pathways regulate specific aspects of each of these phenotypes, specialized chromosomal terminal structures, termed telomeres act as essential regulators of both cell life span and chromosomal integrity (Ref.1).
Telomeres are dynamic DNA-protein complexes that cap the ends of linear chromosomes, preventing detrimental chromosome rearrangements...
References:
-
Telomere regulation in pluripotent stem cells.
Protein Cell. 2014 Mar;5(3):194-202. doi: 10.1007/s13238-014-0028-1. Epub 2014 Feb 22. Review. -
The asymmetry of telomere replication contributes to replicative senescence heterogeneity.
Sci Rep. 2015 Oct 15;5:15326. doi: 10.1038/srep15326. -
Control of telomerase action at human telomeres.
Nat Struct Mol Biol. 2015 Nov;22(11):848-52. doi: 10.1038/nsmb.3083. -
Replication of telomeres and the regulation of telomerase.
Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a010405. doi: 10.1101/cshperspect.a010405. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions